Course Code	Semester	Course Name	LE/RC/LA	Course Type	Language of Instruction	ECTS
MBG6002	6	Molecular Genetics II	3/0/0	CC	Turkish	6

Course Goals	Understanding the relationship between genotype and phenotype in prokaryotic and eukaryotic organisms, learning the regulation of gene expression with respect to cellular differentiation and environmental conditions, understanding the mechanims of gene expression before transcription, during initiation of transcription, and initiation of translation, comprehension of the properties and roles of regulatory proteins in the regulation of gene expression, learning the extrachromosomal genetic systems in prokaryotic and eukaryotic organisms, learning the mechanims of recombination, transposition and mutation and how they cause a change in the genetic information
Prerequisite(s)	-
Corequisite(s)	-
Special Requisite(s)	-
Instructor(s)	Assist. Prof. Dr. Burcu Ayhan Şahin, Assist. Prof. Dr. Sinan Meriç
Course Assistant(s)	-
Schedule	-
Office Hour(s)	Weekdays, Molecular Biology and Genetics Department, M-1-03
Teaching Methods and Techniques	- Power point presentation - Lecture - Discussion - Independent study - Animaiton and vidoes - Internet reserach
Principle Sources	- Watson, Baker, Bell, Gann, Levine, Losick, Molecular Biology of the Gene, 6th Edition, Pearson Publications, 2008 (ISBN: 978-0805395921) - Turner, McLennan, Bates, White, Moleküler Biyoloji, Önemli Notlar, Çeviri editörü Prof.Dr. Muhsin Konuk,  Nobel Kitapevi, 2004 (ISBN: 9789755915968) - Russell, iGenetics : A Molecular Approach, 3rd Edition, Pearson Publications, 2009 (ISBN: 978-0-321-56976-9) - Eliot, Ladomery, Molecular Biology of RNA, Oxford Publications, 2011 (ISBN: 978-0-19-928837-3)
Other Sources	- http://www.dnalc.org/resources/animations/ - http://highered.mcgraw-hill.com/sites/0072835125/student_view0/animations.html# - http://www.dnatube.com/ - http://www.web-books.com/BookInfo.php?BookID=1 - http://learn.genetics.utah.edu/

Course Schedules
Week	Contents	Learning Methods
1. Week	Genotype versus phenotype and the importance of the regulation of gene expression	Oral presentation
2. Week	Regulation of gene expression in prokaryotes; Regulation of gene expression at the level of transcriptional initiation; Positive control, Negative control	Oral presentation
3. Week	Alternative sigma factors; Allosteric interactions; Regulation of gene expression at the level of translational initiation; Autoregulation of ribosomal genes	Oral presentation
4. Week	Regulation of gene expression in eukaryotes; Regulation of gene expression at the level of transcriptional initiation; Role of nucleosome structure in the regulation of gene expression; Regulatory proteins; Conserved DNA binding motifs in regulatory proteins; Activation domains of regulatory proteins	Oral presentation
5. Week	Activators (Enhancers); Loops and insulators; Signal integration; Combinational control; Transcriptional repressors; Signal transduction and the role of transcriptional regulatory proteins; Gene silencing	Oral presentation
6. Week	Epigenetics; Regulation of gene expression at the level of initiation of translation; Regulation of alternative splicing	Oral presentation
7. Week	Midterm I; Regulatory RNA's	Oral presentation
8. Week	The mechanism of RNAi	Oral presentation
9. Week	Extrachromosomal genetic systems in prokaryotes; Extrachromosomal genetic systems in eukaryotes	Oral presentation
10. Week	Homolog recombination	Oral presentation
11. Week	Site-specific recombination	Oral presentation
12. Week	Midterm II; Gene transfer mechanisms in prokaryotes	Oral presentation
13. Week	Transposition	Oral presentation
14. Week	Mutation and classification of mutations; DNA repair mechanisms	Oral presentation
15. Week	Final exam
16. Week	Final exam
17. Week	Final exam

Assessments
Evaluation tools	Quantity	Weight(%)
Midterm(s)	1	40
Attendance	1	10
Final Exam	1	50

Program Outcomes PO-1 To apply all knowledge about basic sciences such as mathematics, physics, chemistry and biology to all problems in molecular biology and genetics PO-2 To be able to identify, model and produce solutions against to problems related to molecular biology and genetics PO-3 To start a procedure, proceed and finalize about determined problem by using analytical techniques PO-4 To be able to understand all knowledge about living organisms which is main subject of molecular biology and genetics PO-5 To contribute scientific research and development and add further information PO-6 To be able to analyze data, design an experiment and proceed and annoate the results PO-7 To be able to use current techniques and analysis methods in molecular biology and genetics PO-8 To be able to be a part of a team in disciplinary or multidisciplinary, national or international public problems focused projects and use at least one foreign language for vocational purposes PO-9 To be able to behave individually, take initiative and creativity skills PO-10 To communicate briefly and clear using oral or written presentation skills to present individual working performance and independent decisions PO-11 To carry responsibility to vocational and ethical issues PO-12 To be aware about quality assessment PO-13 To adopt in principle the importance of life-learning subject and graduate self-development by following new literature about field and apply current knowledge

Learning Outcomes LO-1 Learning the regulation of gene expression in prokaryotic and eukaryotic organisms. LO-2 Understanding the extrachromosomal genetic systems in prokaryotic and eukaryotic organisms. LO-3 Learning the mechanisms of natural and unnatural systems causing a change in the genetic information in prokaryotes and eukaryotes. LO-4 Gaining the ability to comprehend a molecular mechanism from a figure and to draw a figure for a given molecular mechanism. LO-5 Gaining the ability to draw conclusions for a given problem and to discuss the results based on scientific background.

Course Assessment Matrix:

PO 1

PO 2

PO 3

PO 4

PO 5

PO 6

PO 7

PO 8

PO 9

PO 10

PO 11

PO 12

PO 13

LO 1

LO 2

LO 3

LO 4

LO 5