It is aimed to teach structural and molecular properties of cell membrane, molecular basis of muscle contraction, vesicle trafficking, signal transduction pathways. This course is going to provide a detailed understanding about fundamentals of molecular biological sciences to discuss future studies at graduate level.
Prerequisite(s)
-
Corequisite(s)
-
Special Requisite(s)
-
Instructor(s)
Professor Çimen Atak
Course Assistant(s)
-
Schedule
Monday 11.00-13.00 ve Thursday 13.00-14.00, MOBIGEN Seminar Hall
Office Hour(s)
Everyday, MOBIGEN building, Atakoy Campus
Teaching Methods and Techniques
Lectures (ppt presentation, demonstration (video and animation)
Principle Sources
Molecular Biology of the Cell. Bruce Alberts et al. 2007, Publisher: Garland Science
Medical Cell Biology. S.R. Goodmann, 2008, Academic Press
Other Sources
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Course Schedules
Week
Contents
Learning Methods
1. Week
The history of molecular cell biology
Lecture (ppt prensations), Demonstration (animation and video)
2. Week
Structure of cell membrane, Biochemical properties of the membranes
1st quiz
Lecture (ppt prensations), Demonstration (animation and video)
3. Week
Membrane proteins, purification of membrane proteins, lipid-protein distribution of the membranes
Lecture (ppt prensations), Demonstration (animation and video)
4. Week
Diffusion, osmosis and Donnan equilibrum
2nd quiz
Lecture (ppt prensations), Demonstration (animation and video)
5. Week
Membrane transport and active membrane transport
Lecture (ppt prensations), Demonstration (animation and video)
Lecture (ppt prensations), Demonstration (animation and video)
7. Week
Muscle contraction, phsyological anatomy of the skeletal muscle, molecular mechanism of the muscle contraction
Lecture (ppt prensations), Demonstration (animation and video)
8. Week
Actin and myosin filaments, neuro-muscular junction and neuromuscular impulse
3rd quiz
Lecture (ppt prensations), Demonstration (animation and video)
9. Week
Smooth muscle and the regulation of contraction, calcium-calmodulin relation
2nd midterm exam
Lecture (ppt prensations), Demonstration (animation and video)
10. Week
Cell behavior, movements in non muscle cells, movements with microtubules, cilia and flagellae
Lecture (ppt prensations), Demonstration (animation and video)
11. Week
Vesicular traffic,king transport from the Endoplasmic Reticulum through the Golgi apparatus, transport from the Trans Golgi Network to lysosomes
4th quiz
Lecture (ppt prensations), Demonstration (animation and video)
12. Week
Transport from the plasma membrane to endosome, trancytosis, exocytosis, secretory vesicles, synaptic vesicles, coated vesicles
Lecture (ppt prensations), Demonstration (animation and video)
13. Week
Main mechanism of cell signalling, extracellular signal molecules, receptor types, ligand-receptor relations
5th quiz
Lecture (ppt prensations), Demonstration (animation and video)
14. Week
Protein phosphorylation, kinases and phosphatases, cyclic nucleotides, cyclases and G proteins
Lecture (ppt prensations), Demonstration (animation and video)
15. Week
16. Week
17. Week
Assessments
Evaluation tools
Quantity
Weight(%)
Midterm(s)
2
20
Quizzes
4
20
Homework / Term Projects / Presentations
2
5
Attendance
1
5
Final Exam
1
50
Program Outcomes
PO-1
To apply all knowledge about basic sciences such as mathematics, physics, chemistry and biology to all problems in molecular biology and genetics
PO-2
To be able to identify, model and produce solutions against to problems related to molecular biology and genetics
PO-3
To start a procedure, proceed and finalize about determined problem by using analytical techniques
PO-4
To be able to understand all knowledge about living organisms which is main subject of molecular biology and genetics
PO-5
To contribute scientific research and development and add further information
PO-6
To be able to analyze data, design an experiment and proceed and annoate the results
PO-7
To be able to use current techniques and analysis methods in molecular biology and genetics
PO-8
To be able to be a part of a team in disciplinary or multidisciplinary, national or international public problems focused projects and use at least one foreign language for vocational purposes
PO-9
To be able to behave individually, take initiative and creativity skills
PO-10
To communicate briefly and clear using oral or written presentation skills to present individual working performance and independent decisions
PO-11
To carry responsibility to vocational and ethical issues
PO-12
To be aware about quality assessment
PO-13
To adopt in principle the importance of life-learning subject and graduate self-development by following new literature about field and apply current knowledge
Learning Outcomes
LO-1
To be able to understand structural and molecular properties of membranes
LO-2
To distinguish types of ion channels, their molecular properties, the potential of membranes and actions
LO-3
To learn molecular structure of muscle tissue and contraction process
LO-4
To learn the molecular properites of cell movement types
LO-5
To learn vesicle traficking between endoplasmic reticulum, golgi, endosome and lysosome membranes at molecular level
LO-6
To understand signal molecules and signalling networks in the cell
