In this course, students are going to learn the molecular basis of cancer development and progression. Students want to work in cancer biology field can understand the fundamentals of cancer biology and therapeutic approaches for their future study subjects
Prerequisite(s)
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Corequisite(s)
-
Special Requisite(s)
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Instructor(s)
Professor Seyhan Altun
Course Assistant(s)
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Schedule
2 hours in a week, MOBIGEN seminar room, Atakoy Campus
Office Hour(s)
Everyday, MOBIGEN building, Atakoy Campus
Teaching Methods and Techniques
Lectures (ppt presentation), demonstration (video and animations)
Principle Sources
L. Pecorıno 2009. Molecular Biology of Cancer. Mechanisms, Targets and Therapeutics. Oxford University Press
M. Knowles And P. Selby, 2007. Introduction to the Cellular and Molecular Biology Of Cancer. Oxford University Press
S. Pelengaris and M. Khan, 2006. The Molecular Biology Of Cancer. Blackwell Publishing
Other Sources
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Course Schedules
Week
Contents
Learning Methods
1. Week
The definition cancer, properties and general terms
2. Week
Gene structure, mutations, carcinogenic agents, chemical carcinogens
3. Week
Quiz
DNA repair mechanism, therapeutic strategies
4. Week
The regulation of gene expression, transcriptional factors,
5. Week
Quiz
MicroRNAs, chromatin structure
6. Week
Quiz
Epigenetic regulation and carcinogenesis
7. Week
Mid-term exam
8. Week
Telomers, telomerase, epigenomic and histonomic drugs
9. Week
Growth factor signaling pathway, oncogenes
Quiz
10. Week
Cell cycle, cyclins, cyclin dependent kinases, cell cycle and cancer
Mid-term exam
11. Week
Tumor suppressor genes, Rb and p53
Quiz
12. Week
DNA repair, angiogenesis, p53 mutations and cancer
13. Week
Molecular therapeutic strategies
Quiz
14. Week
The definition of apoptosis at cellular and molecular level, chemotherapy and cancer
15. Week
Final exam week
16. Week
Final exam week
17. Week
Final exam week
Assessments
Evaluation tools
Quantity
Weight(%)
Midterm(s)
2
20
Quizzes
4
20
Homework / Term Projects / Presentations
2
5
Attendance
1
5
Final Exam
1
50
Program Outcomes
PO-1
To apply all knowledge about basic sciences such as mathematics, physics, chemistry and biology to all problems in molecular biology and genetics
PO-2
To be able to identify, model and produce solutions against to problems related to molecular biology and genetics
PO-3
To start a procedure, proceed and finalize about determined problem by using analytical techniques
PO-4
To be able to understand all knowledge about living organisms which is main subject of molecular biology and genetics
PO-5
To contribute scientific research and development and add further information
PO-6
To be able to analyze data, design an experiment and proceed and annoate the results
PO-7
To be able to use current techniques and analysis methods in molecular biology and genetics
PO-8
To be able to be a part of a team in disciplinary or multidisciplinary, national or international public problems focused projects and use at least one foreign language for vocational purposes
PO-9
To be able to behave individually, take initiative and creativity skills
PO-10
To communicate briefly and clear using oral or written presentation skills to present individual working performance and independent decisions
PO-11
To carry responsibility to vocational and ethical issues
PO-12
To be aware about quality assessment
PO-13
To adopt in principle the importance of life-learning subject and graduate self-development by following new literature about field and apply current knowledge
Learning Outcomes
LO-1
To learn the structure of DNA, stability, repair mechanism and chemical carcinogens
LO-2
To discuss the transcriptional regulation mechanism, epigenetics and telomers
LO-3
To understand the cell cycle and cancer, cyclin dependent kinases and their therapeutic utilization
LO-4
To learn growth factors and cancer progression, oncogenes, cell signaling network and cancer
