In this course it is aimmed to discuss on following subjects: Histone modifications, epigenetic regulations of genes, DNA methyl transferases, chromatin structure remodelling, genomic imprinting, epigenetic analysis methods, DNA methylation and cancer cases, anormal imprinting related illnesses, DNA methylation and repeating instability illnesses, the role of DNA methylation in developmental biology, embryogenic stem cells and differentiation, epigenetic approaches in other organisms.
Prerequisite(s)
-
Corequisite(s)
-
Special Requisite(s)
-
Instructor(s)
Assist. Prof. Dr. Burcu Ayhan Şahin
Course Assistant(s)
-
Schedule
Friday, 11.00-13.00, MOBİGEN Lab2
Office Hour(s)
Everyday MOBIGEN Atakoy Campus
Teaching Methods and Techniques
-Discussion and presentation
Principle Sources
-www.pubmed.com
Other Sources
-
Course Schedules
Week
Contents
Learning Methods
1. Week
Definition of epigenetics
Oral presentation, discussion
2. Week
Histone modifications and epigenetic gene regulation
Oral presentation, discussion
3. Week
Histone modifications and epigenetic gene regulation
Oral presentation, discussion
4. Week
DNA methyltransferases
Oral presentation, discussion
5. Week
Methyl-binding proteins and chromatin material regulation
Oral presentation, discussion
6. Week
Epigenetic analysis methods
Oral presentation, discussion
7. Week
Epigenetic analysis methods
Oral presentation, discussion
8. Week
MIDTERM EXAM
-
9. Week
DNA methylation and pathophysiological diseases
Oral presentation, discussion
10. Week
DNA methylation and pathophysiological diseases
Oral presentation, discussion
11. Week
Genomic imprinting
Oral presentation, discussion
12. Week
Epigenetic factors in developmental biology
Oral presentation, discussion
13. Week
Epigenetic factors in stem cell biology
Oral presentation, discussion
14. Week
Epigenetic regulation mechanisms for other organisms
Oral presentation, discussion
15. Week
FINAL EXAM
-
16. Week
17. Week
Assessments
Evaluation tools
Quantity
Weight(%)
Homework / Term Projects / Presentations
1
40
Final Exam
1
60
Program Outcomes
PO-1
To be able to determine the field related problems and analysis them to find the solutions as a specialist by using the knowledge coming from undergraduate level.
PO-2
To be able to develop and apply research strategies, which depend on the new technological achievements, for novel studies about molecular cell biology, plant biotechnology and molecular genetics fields on the basis of undergraduate qualifications.
PO-3
To be able to discuss field related subjects by using at least one foreign language.
PO-4
To be sensitive against public problems and be able to create solutions to these problems by synthesis of knowledge coming from other disciplines with the abilities and knowledge of the related field
PO-5
To be able to take independent decision in the frame of specialized knowledge and scientific approach about field and lead/proceed a project by using creativity skills.
PO-6
To be able to decide independently during solving the problem and contribute the group labor in harmony.
PO-7
To be able to present information which is supported by quantitative and qualitative data to groups in/outside of the field by written, oral and visually.
PO-8
To consider to behave properly in human rights and scientific ethics at research.
PO-9
To be able to use informatics and communication skills according required level for area.
PO-10
To obtain required quality about field in order to maintain higher academic degree
Learning Outcomes
LO-1
To have knowledge DNA methylation, histon modifications and epigenetic regulation of genes
LO-2
To be able discuss DNA methyltransferases, chromatin remodelling
LO-3
To know genomic imprinting and epigenetic analysis methods
LO-4
To be able discuss the relation between DNA methylation and illnesses DNA metilasyonu
LO-5
To have knowledge about epigenetic modifications in other organisims
