It is aimed to teach at first the chemical structures, biosynthesis and catabolism of the polyamines and then it is going to be discuss the relations of them with cell cycle events, apoptosis, and the roles of polyamines in different cancer types. The objective of this course also is to teach the role of polyamine biosynthetic inhibitors and analogues in different cancer types and their biomarker evaluation in cancer prognosis and in therapeutics. In addition it is aimed to teach their role in plant growth and development and stress. Therefore on basis these polyamine backround students going to be able to learn and to design their research projects in different types of cancer and plants on molecular level and also they can be able to use polaymines as molecular tool in cancer treatments.
- Lectures, ppt , video and animation presentations
Principle Sources
-J.Y. Wang R.A. Casero. (Eds.) Polyamine Cell Signalling. Physiology, Pharmacology and Cancer Reesearch. Humana Press, 2006.
H.E. Wallace (Ed.) Essays in Biochemistry.The Polaymines small molecules in the 'Omic' era. Portland Press, 2009.
S. Bardoz and A. White. Polyamines in Helath and Nutrition. Kluwer Academic Publishers, 1999.
R.D. Slocum and H.E. Flores. Biochemistry and Physiology of Polaymines in Plants. CRC Press, 1991.
Other Sources
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Course Schedules
Week
Contents
Learning Methods
1. Week
Introduction to the polyamines and their biosynthesis
Lecture (ppt presentations), animations and videos
2. Week
Polyamine catabolism
Lecture (ppt presentations and videos
3. Week
Polyamine inhibitors, analogues and uncommon polyamines
Lecture (ppt presentations) animations, videos
4. Week
Polyamine homeostasis and antyzymes
Lecture (ppt presentations), animations and videos
5. Week
S-adenosylmethionine decarboxylase
Lecture (ppt presentations), animations and videos
6. Week
Cell cycle and polyamines
Lecture (ppt presentations), animations and videos
7. Week
Cell signalling mechanism in relation with polyamines
Lecture (ppt presentations), animations and videos
8. Week
Apoptosis and polyamine relations
Lecture (ppt presentations), animations and videos
9. Week
Polyamines in cancer
Lecture (ppt presentations), animations and videos
10. Week
Drug designs targeting polyamine basis
Lecture (ppt presentations), animations and videos
11. Week
Polyamine functions in plants
Lecture (ppt presentations), animations and videos
12. Week
Nutrition and polyamines
Lecture (ppt presentations), animations and videos
13. Week
Polyamine detection methods
Lectuıre (ppt presentations), animations and videos
14. Week
Polyamines in future
Lecture (ppt presentations), animations and videos
15. Week
Final
16. Week
Final
17. Week
Final
Assessments
Evaluation tools
Quantity
Weight(%)
Program Outcomes
PO-1
To be able to determine the field related problems and analysis them to find the solutions as a specialist by using the knowledge coming from undergraduate level.
PO-2
To be able to develop and apply research strategies, which depend on the new technological achievements, for novel studies about molecular cell biology, plant biotechnology and molecular genetics fields on the basis of undergraduate qualifications.
PO-3
To be able to discuss field related subjects by using at least one foreign language.
PO-4
To be sensitive against public problems and be able to create solutions to these problems by synthesis of knowledge coming from other disciplines with the abilities and knowledge of the related field
PO-5
To be able to take independent decision in the frame of specialized knowledge and scientific approach about field and lead/proceed a project by using creativity skills.
PO-6
To be able to decide independently during solving the problem and contribute the group labor in harmony.
PO-7
To be able to present information which is supported by quantitative and qualitative data to groups in/outside of the field by written, oral and visually.
PO-8
To consider to behave properly in human rights and scientific ethics at research.
PO-9
To be able to use informatics and communication skills according required level for area.
PO-10
To obtain required quality about field in order to maintain higher academic degree
Learning Outcomes
LO-1
To learn the polyamine biosynthetic, catabolic pathways ,mechanism of the PA inhibitorsand analogues
LO-2
To learn the relations of polyamines with cell cycle events, apoptosis, cell signalling mechanisms
LO-3
The molecular roles of polyamines in different cancer types
LO-4
To learn how to use polyamines in diagnosis and therapeutic roles in different cancers
by targeting their molecular roles
LO-5
Nutritional roles of polyamines
LO-6
To learn the polyamines relations with plant stress mechanism
