The aim of the course is to learn various model organisms genomic structure, comprehend the functional genomics, pharmacogenomics, nutriogenomics, toxicogenomics and also protein-protein interactions, post-translational modification of protemics applications by discusing scientific papers
Prerequisite(s)
-
Corequisite(s)
-
Special Requisite(s)
Advanced Ingilish
Instructor(s)
Assist. Prof. Dr. Alp Ayan
Course Assistant(s)
Schedule
Not determined
Office Hour(s)
Not determined
Teaching Methods and Techniques
- Oral presentation
- Demonstration
- Discussion
- Scientific paper
Principle Sources
-
1- Genomics: Essential Methods, Mike Starkey (Editor), Ramnath Elaswarapu (Editor), Wiley-Blackwell; 1 edition, 2004.
2- Essentials of Genomic and Personalized Medicine, Geoffrey S. Ginsburg (Editor), Huntington Ph.D Willard (Editor), Academic Press; 1 edition, 2009.
3- Comparative Toxicogenomics, Volume 2 (Advances in Experimental Biology), Christer Hogstrand (Editor), Pete Kille (Editor), Elsevier Science; 1 edition, 2008.
4- Genomics: Applications in Human Biology Sandy B. Primrose (Author), Richard Twyman (Author), Wiley-Blackwell; 1 edition, February 9, 2004.
5- Introducing Proteomics: From concepts to sample preparation, mass spectrometry and data analysis, josip Lovric, Wiley-Blackwell, 2011
6- Intoduction to Proteomics: Principles and Applications (Methods of Biochemical Analysis), Nawin C.Mishra, Wiley, 2010
7- Proteomics in Practice: A guide to successful experimental design. Reiner Westermeier, Tom Naxen, Hans-Rudolf Höpker, Wiley-VCH, 2008
8- Introduction to proteomics, Agnieszka Kraj, Jerzy Silberring (Eds.), Wiley, 2008.
Other Sources
-www.ncbi.nlm.nih.gov
www.sciencedirect.com
Course Schedules
Week
Contents
Learning Methods
1. Week
Introduction to Prokaryotic and Eukaryotic genom and comperative genomics
oral presentation, demonstration
2. Week
The techniques in functional genomic applications and experimental strategies
oral presentation, demonstration, paper discussion
3. Week
Genomic applications in human genetic diseases
oral presentation, demonstration, paper discussion
4. Week
Midterm
Analysis and synthesis
5. Week
Pharmacogenetic and Pharmacogenomics applications
oral presentation, demonstration, paper discussion
6. Week
Toxicogenomics applications
oral presentation, demonstration, paper discussion
7. Week
Nutriogenomics applications
oral presentation, demonstration, paper discussion
8. Week
Definition of the proteomics and the relation between genomic and system biology
oral presentation, demonstration, paper discussion
9. Week
Introduction to experimental strategies in proteomics, gel-based separations, screeening of protein/peptide in gels, chips in proteomic applications
oral presentation, demonstration, paper discussion
10. Week
Proteomics of protein modifications, proteomics of protein-protein interactions
oral presentation, demonstration, paper discussion
11. Week
Midterm
Analysis and synthesis
12. Week
Analysis of peptide/proteins by mass spectroscopy, basic principles of application
oral presentation, demonstration, paper discussion
13. Week
Coanalysis of mass spectoscopy and proteomic data
oral presentation, demonstration, paper discussion
14. Week
Bioinformatic approaches in mass spectroscopy-proteom data, proteomic application strategies
oral presentation, demonstration, paper discussion
15. Week
Final exam
Analysis and synthesis
16. Week
Final exam
Analysis and synthesis
17. Week
Final exam
Analysis and synthesis
Assessments
Evaluation tools
Quantity
Weight(%)
Midterm(s)
2
60
Final Exam
1
40
Program Outcomes
PO-1
To be able to determine the field related problems and analysis them to find the solutions as a specialist by using the knowledge coming from undergraduate level.
PO-2
To be able to develop and apply research strategies, which depend on the new technological achievements, for novel studies about molecular cell biology, plant biotechnology and molecular genetics fields on the basis of undergraduate qualifications.
PO-3
To be able to discuss field related subjects by using at least one foreign language.
PO-4
To be sensitive against public problems and be able to create solutions to these problems by synthesis of knowledge coming from other disciplines with the abilities and knowledge of the related field
PO-5
To be able to take independent decision in the frame of specialized knowledge and scientific approach about field and lead/proceed a project by using creativity skills.
PO-6
To be able to decide independently during solving the problem and contribute the group labor in harmony.
PO-7
To be able to present information which is supported by quantitative and qualitative data to groups in/outside of the field by written, oral and visually.
PO-8
To consider to behave properly in human rights and scientific ethics at research.
PO-9
To be able to use informatics and communication skills according required level for area.
PO-10
To obtain required quality about field in order to maintain higher academic degree
Learning Outcomes
LO-1
To distinguish the genomik structure of various organisms by using comperative genomics
LO-2
To comprehend the genomic application fields by the knowledge gained from functional genomic principles
LO-3
To analyze the problems in toxicogenomics, pharmacogenomics, nutriogenomics and create new approaches by functional genomic methods
LO-4
Comparison of classical approaches to understanding protein structure and function with recent proteomic approaches.
LO-5
Describe proteomic approaches and techniques used to investigate protein structure and function.
LO-6
Explain how specific proteomics techniques can contribute and analyse to understanding of biological systems.
