Graduate
Institute of Graduate Studies
Molecular Biology And Genetics
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Advanced Molecular Genetics

Course CodeSemester Course Name LE/RC/LA Course Type Language of Instruction ECTS
FMG0016 Advanced Molecular Genetics 3/0/0 DE Turkish 8
Course Goals
In this course it is aimed to be learnt the basic properties of nucleic acid molecules shaping the organism's genetic information, understanding the chromosomal organization and packaging in prokaryotic and eukaryotic organisms, understanding the mechanism of DNA replication, learning the transcription and translation in gene expression in prokaryotic and eukaryotic organisms with comparison between the organisms, learning the basics of genetic code, Understanding the relationship between genotype and phenotype in prokaryotic and eukaryotic organisms, learning the regulation of gene expression with respect to cellular differentiation and environmental conditions, understanding the mechanims of gene expression before transcription, during initiation of transcription, and initiation of translation, comprehension of the properties and roles of regulatory proteins in the regulation of gene expression, evaluating the gene control levels during cell signalig, embriyonic development, cancer and human genetic diseases
Prerequisite(s) -
Corequisite(s) -
Special Requisite(s) -
Instructor(s) Professor Çimen ATAK
Course Assistant(s) -
Schedule Not determined yet
Office Hour(s) Everyday, MOBIGEN building, Atakoy Campus 4349 interior
Teaching Methods and Techniques -Lecture and discussion
Principle Sources - Watson, Baker, Bell, Gann, Levine, Losick, Molecular Biology of the Gene, 6th Edition, Pearson Publications, 2008 (ISBN: 978-0805395921)

- Turner, McLennan, Bates, White, Moleküler Biyoloji, Önemli Notlar, Çeviri editörü Prof.Dr. Muhsin Konuk,  Nobel Kitapevi, 2004 (ISBN: 9789755915968)

- Russell, iGenetics : A Molecular Approach, 3rd Edition, Pearson Publications, 2009 (ISBN: 978-0-321-56976-9)

- Eliot, Ladomery, Molecular Biology of RNA, Oxford Publications, 2011 (ISBN: 978-0-19-928837-3)

Other Sources - http://www.dnalc.org/resources/animations/

- http://highered.mcgraw-hill.com/sites/0072835125/student_view0/animations.html#

- http://www.dnatube.com/

- http://www.web-books.com/BookInfo.php?BookID=1

- http://learn.genetics.utah.edu/

Course Schedules
Week Contents Learning Methods
1. Week Levels of Gene Control Lecture, discussion
2. Week Structure of Chromatin Lecture, discussion
3. Week Role of Chromatin Structure in Gene Control Lecture, discussion
4. Week The Process of Transcription Lecture, discussion
5. Week Transcription Factors and Transcription Control Lecture, discussion
6. Week Post-transcriptional Process and regulation Lecture, discussion
7. Week Mid term
8. Week Gene Control and Cellular Signaling Pathway Lecture, discussion
9. Week Gene Control in Embriyonic Development Lecture, discussion
10. Week Control of Cell-type specific gene expression Lecture, discussion
11. Week Gene Regulation and Cancer Lecture, discussion
12. Week Gene Regulation and Human Diseases Lecture, discussion
13. Week Presentation Presentation
14. Week Presentation Presentation
15. Week Final exam week
16. Week Final exam week
17. Week Final exam week
Assessments
Evaluation tools Quantity Weight(%)
Midterm(s) 1 40
Project(s) 1 20
Final Exam 1 40


Program Outcomes
PO-1To be able to determine the field related problems and analysis them to find the solutions as a specialist by using the knowledge coming from undergraduate level.
PO-2To be able to develop and apply research strategies, which depend on the new technological achievements, for novel studies about molecular cell biology, plant biotechnology and molecular genetics fields on the basis of undergraduate qualifications.
PO-3To be able to discuss field related subjects by using at least one foreign language.
PO-4To be sensitive against public problems and be able to create solutions to these problems by synthesis of knowledge coming from other disciplines with the abilities and knowledge of the related field
PO-5To be able to take independent decision in the frame of specialized knowledge and scientific approach about field and lead/proceed a project by using creativity skills.
PO-6To be able to decide independently during solving the problem and contribute the group labor in harmony.
PO-7To be able to present information which is supported by quantitative and qualitative data to groups in/outside of the field by written, oral and visually.
PO-8 To consider to behave properly in human rights and scientific ethics at research.
PO-9To be able to use informatics and communication skills according required level for area.
PO-10To obtain required quality about field in order to maintain higher academic degree
Learning Outcomes
LO-1To have knowledge about DNA as a genomic material and its regulation
LO-2To know regulation of genomic regulation in prokaryotic and eukaryotic organisms
LO-3To be able to understand the information flow coming from genomic material in prokaryotes and eukaryotes
LO-4To be able to solve problems about molecular genetics
LO-5To have knowledge about application field of molecular genetics
Course Assessment Matrix:
Program Outcomes - Learning Outcomes Matrix
 PO 1PO 2PO 3PO 4PO 5PO 6PO 7PO 8PO 9PO 10
LO 1
LO 2
LO 3
LO 4
LO 5