In this course, epigenetic concepts, DNA methylation, histone modifications, epigenetic mechanisms of gene regulation, DNA methyltransferases, methyl-binding proteins and their relationship with chromatin, genomic imprinting, Epigenetic analysis methods, DNA methylation and cancer, diseases associated with abnormal imprinting, DNA methylation and repetitive instability diseases, role of DNA methylation in human development, embryonic stem cells and differentiation, epigenetic approaches in other organisms.
Prerequisite(s)
-
Corequisite(s)
-
Special Requisite(s)
Course includes active paper journal club activities.
Instructor(s)
Professor Seyhan Altun
Course Assistant(s)
-
Schedule
-
Office Hour(s)
Elif Damla Arısan, MOBIGEN building, every week day
Teaching Methods and Techniques
-Oral presentation, analysis of articles
Principle Sources
--www.sciencedirect.com
WOS
www.pubmed.com
Other Sources
-
Course Schedules
Week
Contents
Learning Methods
1. Week
Introduction of Epigenetics
Oral presentation
2. Week
Epigenetic mechanisms: Histone modifications and epigenetic gene regulation
Oral presentation
3. Week
Epigenetic mechanisms: Histone modifications and epigenetic gene regulation
Analysis
4. Week
DNA methyltransferases
Oral presentation
5. Week
DNA methyltransferases
Analysis
6. Week
Epigenetic analysis methods
Oral presentation
7. Week
Epigenetic analysis methods
Analysis
8. Week
Mid-term
9. Week
Modifications
Oral presentation
10. Week
TET-protein family
Analysis
11. Week
Epigenetic functioning in different organisms
Analysis
12. Week
Epigenetic functioning in different organisms
Analysis
13. Week
Epigenetic functioning in different organisms
Analysis
14. Week
Epigenetic functioning in different organisms
Analysis
15. Week
Final
16. Week
Final
17. Week
Final
Assessments
Evaluation tools
Quantity
Weight(%)
Midterm(s)
1
40
Homework / Term Projects / Presentations
1
20
Final Exam
1
40
Program Outcomes
PO-1
To apply all knowledge about basic sciences such as mathematics, physics, chemistry and biology to all problems in molecular biology and genetics
PO-2
To be able to identify, model and produce solutions against to problems related to molecular biology and genetics
PO-3
To start a procedure, proceed and finalize about determined problem by using analytical techniques
PO-4
To be able to understand all knowledge about living organisms which is main subject of molecular biology and genetics
PO-5
To contribute scientific research and development and add further information
PO-6
To be able to analyze data, design an experiment and proceed and annoate the results
PO-7
To be able to use current techniques and analysis methods in molecular biology and genetics
PO-8
To be able to be a part of a team in disciplinary or multidisciplinary, national or international public problems focused projects and use at least one foreign language for vocational purposes
PO-9
To be able to behave individually, take initiative and creativity skills
PO-10
To communicate briefly and clear using oral or written presentation skills to present individual working performance and independent decisions
PO-11
To carry responsibility to vocational and ethical issues
PO-12
To be aware about quality assessment
PO-13
To adopt in principle the importance of life-learning subject and graduate self-development by following new literature about field and apply current knowledge
Learning Outcomes
LO-1
To be able to define the concepts related to epigenetics
LO-2
To have knowledge about researches about epigenetics
LO-3
Define epigenetic printer, eraser and reader mechanisms
LO-4
Discuss the relationship between epigenetics and disease
