It is aimed to discuss the cancer biology subjects such as cancer and epigenetics, cancer stem cells, cancer immunology, metastasis, infections and inflammation, the possible role of enviromental inducers in cancer development and progression, determination of partners of cancer industry and future aspects in cancer biology topics with new findings in this course.
Molecular Biology and Cancer: Mechanisms, Targets and Therapeutics (2nd edition) -Lauren Pecorino, Oxford University Press
The Molecular Biology of Cancer- Micheal Khan, Stella Plengaris, Wiley-Blackwell
Other Sources
Her dönem önerilen makaleler aşağıdaki dergi grupları ve arama motorlarından verilen anahtar sözcüklere göre öğrenciler tarafından seçilecek veya ders veritabanından sağlanacaktır.
Molecular cancer therapeutics
Oncogene
Course Schedules
Week
Contents
Learning Methods
1. Week
The explanation of course content and reference sources. Introduction to Molecular Cancer Biology II
2. Week
What is epigenetics? The relationship between cancer cases and individual epigenetic variations
Case study
3. Week
The role of epigenetic factors in cancer progression and therapeutical targets
Case study, discussion
4. Week
The definition of stem cells and their hypothetic role in cancer cases.
Case study
5. Week
The molecular characterization of cancer stem cells
Case study, discussion
6. Week
What is metastasis? The malignant cell turn over and spreading potential of cancer cells
Case study
7. Week
Mid-term exam
Analysis and synthesis
8. Week
The definition of possible interaction between infection, inflammation and cancer cases. Molecular targets
Case study, oral presentation
9. Week
Genomic heritage and cancer prognosis
Case study, discussion
10. Week
The investigation of enviromental inducers in malignant cell turnover. Diet and pollution and their molecular targets
Case study, oral presentation, discussion
11. Week
The modelling of possible relationship between obesity and cancer
Case study, discussion
12. Week
The determination of cancer industry partners. The most significant drugs in cancer treatment. The investigation on several molecular targets as biomarkers in cancer therapy
Case study, oral presentation
13. Week
Future strategies on cancer
Case study, discussion
14. Week
The investigation of therapeutical significant targets
Case study, oral presentation
15. Week
Final exam week
16. Week
Final exam week
Analysis and synthesis
17. Week
Final exam week
Project assay delivery
Assessments
Evaluation tools
Quantity
Weight(%)
Midterm(s)
1
20
Homework / Term Projects / Presentations
1
30
Literature discussion
5
25
Final Exam
1
25
Program Outcomes
PO-1
To apply all knowledge about basic sciences such as mathematics, physics, chemistry and biology to all problems in molecular biology and genetics
PO-2
To be able to identify, model and produce solutions against to problems related to molecular biology and genetics
PO-3
To start a procedure, proceed and finalize about determined problem by using analytical techniques
PO-4
To be able to understand all knowledge about living organisms which is main subject of molecular biology and genetics
PO-5
To contribute scientific research and development and add further information
PO-6
To be able to analyze data, design an experiment and proceed and annoate the results
PO-7
To be able to use current techniques and analysis methods in molecular biology and genetics
PO-8
To be able to be a part of a team in disciplinary or multidisciplinary, national or international public problems focused projects and use at least one foreign language for vocational purposes
PO-9
To be able to behave individually, take initiative and creativity skills
PO-10
To communicate briefly and clear using oral or written presentation skills to present individual working performance and independent decisions
PO-11
To carry responsibility to vocational and ethical issues
PO-12
To be aware about quality assessment
PO-13
To adopt in principle the importance of life-learning subject and graduate self-development by following new literature about field and apply current knowledge
Learning Outcomes
LO-1
To define target genes and strategies about several cancer biology subjects such as epigenetic regulation in cancer development and progression, cancer immunology.
LO-2
To be able to discuss current applications and strategies related to molecular mechanism ofcancer biology
LO-3
To define metastatic cancer development and progression stages
LO-4
To be able to define and discuss therapeutic targets
LO-5
To be able to define sub-branches of molecular cancer biology, to learn the importance of enviromental and genomic risk factors related to cancer progression, to be able to put forward strategic global approaches in the fight against cancer
