Hypothesis in aging biology, telomere and telomerases, the molecular markers of cell fate and longevity, the identification of reactive oxygen, nitrogen species, the positive role of reactive oxygen species on cell fate, antioxidation strategies, metabolic rate and aging, cellular senesence, the role of sirtuins in cell longevity, the target of rapalogs and aging, evolution and aging and human progeroid syndromes are going to be discussed in this course.
Prerequisite(s)
NA
Corequisite(s)
NA
Special Requisite(s)
NA
Instructor(s)
Assist. Prof. Dr. Burcu Ayhan Şahin
Course Assistant(s)
TBA
Schedule
TBA
Office Hour(s)
MOBIGEN Building at Atakoy Campus, every work day
Teaching Methods and Techniques
- Lectures, research and discussion
Principle Sources
-Literature based study is recommended.
Other Sources
-
Course Schedules
Week
Contents
Learning Methods
1. Week
Hypothesis in aging biology,
Discussion and research
2. Week
Telomeres and telomerases,
Discussion and research
3. Week
The molecular markers of longevity,
Discussion and research
4. Week
ROS or RNS and aging,
Discussion and research
5. Week
ROS or RNS and aging,
Discussion and research
6. Week
Antioxidation strategies,
Discussion and research
7. Week
Metabolic rate and aging,
Discussion and research
8. Week
Cellular senesence,
Discussion and research
9. Week
The role of sirtuins in cell longevity,
Discussion and research
10. Week
The molecular targets of rapalogs to determine cell fate,
Discussion and research
11. Week
Evolution and aging,
Discussion and research
12. Week
Human progeroid syndromes
Discussion and research
13. Week
Project
Research and presentation
14. Week
Final exam
Recall and combination of previous knowledge with current course content
15. Week
16. Week
17. Week
Assessments
Evaluation tools
Quantity
Weight(%)
Project(s)
1
40
Final Exam
1
60
Program Outcomes
PO-1
To be able to improve the current and advanced level knowledge coming from undergraduate and graduate degree qualifications with originial ideas and/or researches into professional field end to reach the genuine definitions introcuding novelty of science
PO-2
To realise the network of the related field with other interdisciplinary fields, to reach the novel results coming from the analysis, sythesis and evaluation of new and complex ideas
PO-3
To be able to think systematically about the novel ideas in related field
PO-4
To be able to develop a novel scientific technique or to introduce the known technique into a different field
PO-5
To be able to raise qualified individuals that obtain and evaluate the effective scientific results
PO-6
To be able to discuss the scientific results in related field and present them by effective interactive relation strategies
PO-7
To be able to decide strategically to solve the scientific problem and produce the solution
PO-8
To be able to produce solutions to social, scientific and ethical subjects in related field or in industry
PO-9
To be able to discuss field related subjects and to gain ability in effective verbal and visual communication by using at least one foreign language ("European Language Portfolio Global Scale", Level C1).
PO-10
To be able to being a mentor in the novel and interdisciplinary areas that requires the solutions of problems
PO-11
To gain advanced research ability in related field
PO-12
To be able to resarch, design, realise and perform a novel subject
Learning Outcomes
LO-1
To be able to define study focus of aging biology
LO-2
To be able to discuss telomeres and aging biology relationship
LO-3
To have knowledge about cell fate and aging biology relationship
LO-4
To be able to distinguish the potential role of reactive oxygen species in aging biology
LO-5
To be able to define the role of senesence in aging biology
LO-6
To be able to analysis the mechanistic role of several cell signalling cascades in aging biology
